Best Hotels in Mission Valley, United States

We checked thousands of reviews on and to find the best hotels for your stay
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Agenore Barese

Updated: 05 January 2024 · 6 min

Nestled in the heart of the bustling city life yet offering a serene escape, Mission Valley is a prime destination for travelers seeking both adventure and tranquility. This vibrant area, known for its rich history and modern attractions, caters to every kind of visitor, whether you're here for business or pleasure. With an array of hotels in Mission Valley, finding the perfect place to stay is essential for making the most of your visit, offering convenience and comfort close to all major sights.

Choosing the right accommodation in Mission Valley can significantly enhance your travel experience, allowing you easy access to local shopping, dining, and entertainment options. The hotels here range from luxurious resorts to budget-friendly options, ensuring that every traveler finds their ideal match. Recommendations often highlight the importance of considering location, amenities, and customer reviews when selecting your stay, to ensure your chosen hotel meets all your needs.

Insights from seasoned travelers often point to the benefits of staying in Mission Valley hotels, such as exceptional service, picturesque views, and proximity to must-visit destinations like the historic Mission San Diego de Alcalá or the sprawling Mission Bay Park. These accommodations provide not just a place to rest, but a gateway to exploring the best of what Mission Valley and its surroundings have to offer. With each hotel offering its own unique experience, your stay in Mission Valley is guaranteed to be as memorable as the adventures you embark on.
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Our Top 10

(Sorted by rating & number of reviews)

1. New! Condo On Shary
2. Comfort Inn Near Medical Center
3. Shary Inn And Suites
4. Lake Home: Relax And Unwind In Mission Hidden Gem
5. Motel 6-Mission, Tx
6. Clarion Inn & Suites At Sharyland Plantation
7. Surestay Hotel By Best Western Mission
8. Holiday Inn Express Hotel & Suites Mission-Mcallen Area, An Ihg Hotel
9. Casa Rayo De Sol - Private Ranch Guest Home
10. Hampton Inn & Suites Mission

Budget-Friendly Hotels in Mission Valley

Check Availability

Mission
Dec 06, 2025 - Dec 07, 2025

New! Condo On Shary

10.0

Good

(1 Reviews)

+ 7 photos
New! Condo On Shary represents modern convenience and access for guests eager to explore Mission Valley's outdoor offerings. This accommodation features modern amenities and comforts, catering to groups and families who seek adventure. Positioned close to local attractions, it offers a strategic starting point for various outdoor activities. The condo setup allows guests to prepare their meals and rest in a homely environment after a day's explorations.
Address: 5708 Nightingale Unit 2
Rating: Good 10.0 (1 Reviews)

Comfort Inn Near Medical Center

8.1

Good

(96 Reviews)

+ 60 photos
While not traditionally categorized under luxury, the Comfort Inn Near Medical Center elevates the standard with its exceptional service and comfort, making it a notable mention. Guests are treated to well-appointed rooms that offer a tranquil retreat after a day of exploring Mission Valley. The hotel ensures a restful stay with premium bedding, a selection of pillows, and quiet rooms. Additional perks include a hearty breakfast and an outdoor pool for relaxation. Its proximity to the medical center and local attractions adds convenience to luxury, crafting a balanced experience.
Address: 203 South Shary Road
Rating: Good 8.1 (96 Reviews)
Rooms: 52
Price: From 84$

Family-Friendly Hotels in Mission Valley

Mission Valley is not just a destination for solo travelers or couples; it's also a fantastic getaway for families looking for adventure and relaxation. The family-friendly hotels in Mission Valley are designed to accommodate guests of all ages, offering amenities such as kid-friendly pools, spacious rooms, and activities for children. These hotels provide the perfect backdrop for a memorable family vacation, ensuring comfort, entertainment, and convenience for both parents and their little ones. Here, we highlight the accommodations that promise to make your family's stay in Mission Valley extraordinary.

Shary Inn And Suites

8.1

Good

(457 Reviews)

+ 18 photos
Shary Inn and Suites serves as a gateway for guests looking to dive into the adventures that Mission Valley has to offer. The hotel provides comfortable accommodations, essential for resting up after a day full of activities. Its location gives easy access to various local adventure spots, making it a convenient base for explorers. The friendly staff is ready to assist with organizing local tours and providing insights into the best spots for adventure.
Address: 203 South Shary Road
Rating: Good 8.1 (457 Reviews)
Rooms: 50
Price: From 71$

Lake Home: Relax And Unwind In Mission Hidden Gem

+ 33 photos
For adventurers who enjoy water activities, Lake Home offers an exceptional stay. This property is not only a retreat but a direct link to water-based adventures in Mission Valley. Guests can enjoy kayaking, fishing, and more with the lake just steps away. The home provides a comfortable and spacious setting to relax in, with views that inspire and rejuvenate. It’s the perfect spot for those who find their adventure on or near the water, blending comfort and accessibility seamlessly.
Address: 305 Rio Grande Drive
Price: From 345$

Adventure-Ready Hotels in Mission Valley

Adventure seekers planning their stay in Mission Valley will find a variety of hotels ready to cater to their spirited pursuits. These hotels are ideally situated for easy access to outdoor activities, offering amenities like guided tours, gear rentals, and packed lunches. From hiking and biking trails to water sports and exploration, guests can enjoy a full array of activities. The hotels featured in this section understand the needs of the modern adventurer, combining convenience with comfort to help visitors recharge before and after their excursions.

Motel 6-Mission, Tx

7.6

Good

(742 Reviews)

+ 51 photos
Motel 6-Mission stands as a beacon of affordability and convenience in the bustling landscape of Mission Valley. This hotel is perfect for travelers who seek basic, no-frills accommodation that still promises cleanliness, comfort, and friendly service. Guests can enjoy free Wi-Fi throughout the property, ensuring connectivity is never an issue. The outdoor pool is a refreshing oasis in the Texas heat, inviting guests for a leisurely dip. Its location offers easy access to local dining and shopping, making it an excellent base for exploring. For the budget-conscious traveler, Motel 6 presents an unsurpassed blend of value and convenience.
Address: 1813 East Expressway 83
Rating: Good 7.6 (742 Reviews)
Rooms: 83
Price: From 56$

Clarion Inn & Suites At Sharyland Plantation

8.0

Good

(139 Reviews)

+ 148 photos
Clarion Inn & Suites at Sharyland Plantation caters to families with its blend of comfort, convenience, and family-friendly amenities. The hotel greets guests with spacious suites that provide ample room for families to spread out and relax. An outdoor pool, surrounded by lush greenery, offers a tranquil spot for leisure and play. Guests can also enjoy a complimentary hot breakfast, featuring items that cater to various tastes and dietary needs. The hotel’s location near popular attractions and parks makes it an excellent base for families eager to explore everything Mission Valley has to offer. With its thoughtful amenities and welcoming atmosphere, the Clarion Inn & Suites ensures a delightful stay for families of all sizes.
Address: 3700 Plantation Grove Blvd
Rating: Good 8.0 (139 Reviews)
Rooms: 101
Price: From 60$

Surestay Hotel By Best Western Mission

8.1

Good

(394 Reviews)

+ 69 photos
The SureStay Hotel by Best Western Mission offers a stellar experience that strikes a perfect balance between affordability and comfort. This hotel prides itself on its clean, well-appointed rooms that provide a cozy refuge for travelers. With complimentary breakfast, an outdoor swimming pool, and a 24-hour front desk, guests are guaranteed a stay that meets their needs and exceeds expectations. The strategic location allows for easy exploration of Mission Valley’s attractions, making it a preferred choice for those who value both convenience and cost-efficiency. It’s an ideal pick for travelers seeking a wallet-friendly stay without sacrificing the perks of a memorable accommodation experience.
Address: 609 East Interstate Highway 2
Rating: Good 8.1 (394 Reviews)
Rooms: 54
Price: From 60$

Holiday Inn Express Hotel & Suites Mission-Mcallen Area, An Ihg Hotel

9.0

Good

(128 Reviews)

+ 75 photos
The Holiday Inn Express Hotel & Suites in the Mission-McAllen Area is synonymous with comfort and convenience for families. The hotel's inviting atmosphere, combined with its family-oriented amenities, makes it a standout choice. Families can enjoy spacious rooms, a refreshing outdoor pool, and a fitness center. The complimentary Express Start Breakfast is a hit among guests of all ages, offering a variety of choices to kickstart your day. Its strategic location near shopping and entertainment venues adds to its appeal for families looking for a mix of relaxation and activity during their stay in Mission Valley.
Address: 901 South Shary Road
Rating: Good 9.0 (128 Reviews)
Rooms: 85
Price: From 134$

Casa Rayo De Sol - Private Ranch Guest Home

+ 43 photos
Casa Rayo De Sol offers a unique luxury experience in Mission Valley with its private ranch guest home setup. This exclusive property provides guests with a sense of privacy and luxury, set against the backdrop of beautiful landscapes. The home is fully equipped with modern amenities, offering a blend of home comfort and luxury resort living. Guests can enjoy the outdoor pool, spacious living areas, and gourmet kitchen. This private retreat is ideal for families, groups, or couples seeking a luxurious, intimate stay.
Address: 6401 Texas 107

Hampton Inn & Suites Mission

8.6

Good

(343 Reviews)

+ 61 photos
Situated in the center of Mission Valley, Hampton Inn & Suites Mission offers everything a family could ask for—a warm welcome, comfortable rooms, and amenities tailored to guests of all ages. The hotel features an outdoor pool where kids can splash around and adults can unwind. A complimentary breakfast with a variety of options ensures that every family member starts their day right. The rooms are designed to accommodate families, offering ample space and modern comforts. With its close proximity to attractions and dining options, Hampton Inn & Suites stands as an ideal choice for families seeking convenience and a touch of home.
Address: 2505 Victoria Drive
Rating: Good 8.6 (343 Reviews)
Rooms: 107
Price: From 81$

La Quinta By Wyndham Mission At West Mcallen

7.8

Good

(653 Reviews)

+ 77 photos
La Quinta by Wyndham Mission at West McAllen offers guests a comfortable stay with an affordable price tag. This hotel stands out with its spacious rooms, modern amenities, and welcoming atmosphere. Guests can start their day with a complimentary breakfast, featuring a variety of options to cater to different tastes. The outdoor pool and fitness center allow visitors to keep up with their exercise routine or relax after a busy day. Positioned conveniently close to key attractions and shopping areas, La Quinta by Wyndham ensures guests have an enjoyable and hassle-free stay, proving that economical choices can also come with quality and comfort.
Address: 805 Travis Street
Rating: Good 7.8 (653 Reviews)
Rooms: 71
Price: From 75$

For those eager to delve into the heart of Mission Valley’s accommodations, a little research can lead to discovering some of the most comfortable and convenient places to stay. Whether you're looking for the luxurious touch or something more economical, hotels in mission offer a range of options to suit your preferences. These hotels are not just places to sleep, but provide easy access to the Valley’s vibrant nightlife, shopping centers, and dining experiences that reflect the local culture and cuisine. By choosing the right hotel, you get more than just a room; you get a full-fledged experience that enhances your travel, making each moment in Mission Valley unforgettable.

Exploring hotels mission valley san diego reveals a treasure trove of options that cater to the diverse needs of travelers. Whether it's a family vacation, a romantic getaway, or a solo adventure, the area offers accommodations that blend comfort with convenience, ensuring your stay is both enjoyable and hassle-free. These hotels not only put you in close proximity to Mission Valley’s attractions but also provide a sanctuary where you can unwind after a day of exploration. With amenities designed to elevate your stay, from on-site spas to gourmet restaurants, choosing the right hotel can turn a good trip into a great one, allowing you to create memories that last a lifetime.